The rapid digital transformation of health systems globally has brought about significant shifts in how health determinants operate in a digital ecosystem. Digital determinants of health, as highlighted in recent studies by WHO and the London School of Economics (LSE), represent a critical evolution in understanding health outcomes in the 21st century. These determinants include a wide array of factors, such as internet access, digital literacy, algorithmic validation, and data governance, all of which are shaping health outcomes in nuanced and complex ways. Key findings in the report underline the urgency of addressing inequities in digital access and literacy, with particular emphasis on vulnerable populations such as older adults, individuals with disabilities, and those in low-income settings. The report also highlights the disruptive potential of digital technologies, including algorithmic biases, dark commercial patterns, and the spread of misinformation, which can amplify health disparities if not adequately managed. This webinar seeks to unravel the complexity of digital determinants of health and their implications for health systems and policy-making. As part of the ongoing webinar series, Decoding Data and Digital Health, this session aims to provide stakeholders with actionable insights into addressing the digital challenges and opportunities within health systems.